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WHY CBD IS A BETTER REMEDY FOR ANXIETY AND DEPRESSION THAN PHARMACEUTICAL DRUGS

CAN CBD HELP WITH ANXIETY AND DEPRESSION?

Guest post by Davit Tsilosani

Anxiety and depression afflict almost 45% of the world’s adult population, with the WHO stating that over 350 million people worldwide suffer from depression. In the U.S and many parts of the world, this is primarily treated through medication. There a number of pharmaceutical medications approved by the FDA that help to fight depression both in kids and adults. However, these come with the risk of addiction, kidney and liver failure and a host of other complications making them almost as beneficial as they are risky.

Anxiety is good as a natural response. It pushes us to do things we would have otherwise not done in a normal circumstance. However, if it comes in waves and goes unmanaged, the results are usually not as pleasing. Its impact on our daily lives can turn catastrophic, making us less than capable human beings. Unmanaged anxiety is the main cause of anxiety-related disorders like panic disorders, OCD, PTSD and several others. Just like depression, there are several approved medications that help people manage and, in some cases, overcomes such disorders. There are however patients that don’t respond to such medications and others that instantly become addicted.

Anti-depressant and anti-anxiety medication work with an almost 60% success rate. However, this comes with the probability of addiction. This is why there arose the need to seek alternative ways to manage these two conditions. Ways that would not cause more harm than good in the long run. One of these alternative treatments was the use of CBD Oil.

WHAT IS CBD?

Cannabidiol (CBD) is a component of cannabis. It is one of the active cannabinoids in cannabis plants. It is the main component in CBD Oil which usually has very little THC levels. THC is the component of cannabis that is responsible for the psychoactive effects and the high feeling. It is for this reasons that CBD finds several uses in medicine.

WHY IS IT BETTER?

For those that are still considering Pharmaceutical Drugs as their choice treatment, here are the reasons why CBD is a better alternative when it comes to the management of anxiety and depression.

IT IS NATURAL AND RELAXING

The link between CBD and depression has revolutionized how people with anxiety and depression can get treatment to overcome the limitations of their conditions. CBD and CBD Oil products work with the body, helping it to release the right hormones to counter those that the brain in releasing during its constant state of anxiety or depression. This means that you not only get an all natural cure but a cure that works for the good of your body. You will always be in a state of relaxation, ensuring that you are able to go about life the right way.

IT IS MORE EFFECTIVE

While anti-anxiety and antidepressant medications like SSRI focus only on the serotonin receptors, CBD goes the extra mile to stimulate the hippocampal part of the brain. This ensures that while the brain is being flooded by serotonin, it is also being properly stimulated and encouraged to produce more neurons. This makes CBD for anxiety very effective and reduces the time that it takes to rid you of your symptoms and bring your brain back to a normal standing, something that some other pharmaceutical drugs are usually unable to achieve.

NO ADVERSE SIDE EFFECTS

Drugs, especially those that help manage anxiety and depression usually come with a long list of side effects. These are usually written on the prescription bottle. That is not a bad thing, but a requirement by law. What makes them a poor choice is the fact they are bound to inflict almost all of the said side effects on the users. This means that you start out with one problem, anxiety or depression, but end up struggling with close to a dozen things. CBD Oil, on the other hand, is all natural and comes with no such side effects. Though people respond differently to it, the side effects experienced are minimal and don’t affect the quality of life in any way.

YOU DETERMINE YOUR DOSAGE

Unlike SSRI drugs where your dosage is determined then fiddled with over time till an optimum amount is arrived at by your doctor, CBD for anxiety is a freer alternative. You determine how much of it is enough for you at the time and what suits you on a daily basis. This enables you to heal faster and the sense of control motivates your brain to better battle what is afflicting it. It doesn’t get any better than CBD Oil.

VARIETY

When it comes to pills, the only way you can ingest them is through swallowing. Some people tend to mix it up from time to time and grind them before mixing them in their drinks. Research has however shown that the repeated action of swallowing pills a day in day out does harm to the progress that the person tends to make. After some time, it becomes a constant reminder, aggravating the depression or the anxiety. CBD for anxiety does not come with the same problem. CBD can be acquired in solid, liquid and gaseous form. You can actually cook it into your food. Vape it while you go about your daily life or simply chew on the pills while you focus on your work. The number of ways you can take it is only limited by your imagination. The fun that accompanies the medication helps relax the body further, curing you of your condition faster.

If your anxiety or depression are bothering you, then it may be time to look into CBD and depression. We are positive that CBD for anxiety will put a positive spin in your life. With CBD Oil, you cannot go wrong.

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CANNABIS EXTRACTION TECHNIQUES – ALCOHOL EXTRACTION VS CO2

HOW IS YOUR CBD EXTRACTED? CANNABIS EXTRACTION CAN BE A BIT DAUNTING

CANNABIS EXTRACTION? WHAT IS IT?

This is something most people are unaware of, the various cannabis extraction methods used to extract the cannabinoids (THC, CBD etc) and essential oils (terpenes).

We have CO2 (Carbon Dioxide)
There’s Ethanol Alcohol
How about Butane
Isopropyl Alcohol
Propane
Vegetable Oil
Butter

Today we are going to focus on Ethanol and CO2 cannabis extraction because they are the most used when making extracts and tinctures. I personally don’t like the sound of butane, propane or isopropyl alcohol as there is always residue left in the finished product no matter how clean you try to make it. Oils and butters are great for the home crafter, but getting an exact number or mg of THC/CBD per 1oz is difficult to replicate.

ETHANOL CANNABIS EXTRACTION – (FOOD GRADE ALCOHOL)

This is my preferred method of extracting the cannabinoids, it takes longer and is more expensive in the long run, but I believe this is what makes our products work as well as they do.

The hemp flowers are put into large containers and 200 proof food grade alcohol is poured over them and agitated for a few minutes to remove the cannabinoids. The plant/alcohol mixture is then filtered, leaving the alcohol mixture saturated with all of the cannabinoids, terpenes and flavonoids. This mixture is heated to around 150 degrees and the alcohol is cooked off slowly leaving a rich, dark molasses like oil. This oil extract is filled with the goodness and healing qualities of whole plant medicine.

This whole plant cannabis oil is also known as full extract cannabis oil, hemp oil extract, or Rick Simpson Oil (RSO). As a supplement and possible treatment for cancer, whole-plant cannabis oil can be orally administered (in minute quantities) or applied directly to the skin. Sublingual delivery is the preferred method of treatment for many cancer patients. Not only is it a convenient way to medicate, but intake through the oral mucosal membranes in your mouth provides for rapid and effective absorption directly into your systemic circulation because of the increased bioavailability of the cannabinoids.

KANARELIEF USES FOOD GRADE ALCOHOL TO EXTRACT THE CHLOROPHYLL, CANNABINOIDS AND TERPENES!

We take this wonderful rich cannabis oil and infuse it into grape seed oil giving us our very healing Hemp CBD tinctures. Some of our products get added essential oils and herbs, but other than that we add nothing else to our products. They are very clean, no preservatives, no chemicals, nothing you can’t pronounce!

Note: Whole-plant cannabis oil is not the same as “hemp seed oil.” Hemp seed oil is a cold-pressed oil made from the seeds of the hemp plant. It is rich with essential fatty oils and is used mostly for its nutritional benefits. You can easily buy it in health food stores. It often gets mislabeled as “hemp oil,” but it is not. True whole-plant oil derived from the cannabis plant, on the other hand, is made from the buds/flower of the female cannabis plant and is comprised of many different cannabinoids including THC, CBD, CBN, and more — in addition to terpenes, flavonoids and other compounds.

CARBON DIOXIDE (CO2) CANNABIS EXTRACTION

Carbon dioxide (CO2) is a supercritical fluid, meaning it converts into a liquid form when pressurized. At the same time, it is a pure chemical substance that occurs naturally and leaves behind no residues.

Accordingly, the Supercritical CO2 extraction method (aka CO2 extraction) can help ensure cannabis concentrates are pure, making it a good option for patients in search of a natural form of cannabis oil.

SUPERCRITICAL CO2 CANNABIS EXTRACTION IS SAFE BUT IS IT EFFECTIVE?

Supercritical CO2 extraction is already a standard extraction method for the food, dry cleaning and herbal supplement industries. It is a common food additive as well.

In fact, CO2 is used to produce carbonated soft drinks, in the removal of caffeine from coffee beans in order to make decaffeinated coffee, as an environmentally friendly solvent for dry cleaning, and as an extraction solvent when producing essential oils. Supercritical CO2 is also common when pesticides and metals are extracted from agricultural crops.

The CO2 extraction process allows compounds to be extracted with little damage and low toxicity; it utilizes a high pressure vessel containing cannabis.
Supercritical CO2 is inserted into the vessel, and pumped through a filter where it is separated from the plant matter once the pressure is released. Next, the supercritical CO2 evaporates and is dissolved into the cannabinoids.

Now here’s the important part. If CO2 extraction is not done properly it strips the terpenes (essential oils) from the plant leaving only the compounds (THC, CBD). For Whole Plant Therapy it is vital that you get the terpenes as well as the cannabinoids. Lavender would not be lavender if the terpene linalool was removed. Think about it.

THE DIFFERENCE IN PRODUCT BETWEEN ALCOHOL CANNABIS EXTRACTION AND CO2 EXTRACTION

The most important difference here is that the alcohol cannabis extraction retains the chlorophyll. Chlorophyll is very important in that it oxygenates the body creating an alkaline environment. Cancer and other diseases cannot survive in an alkaline environment. It also retains the Terpenes (essential oils) which are the essence of the plant and one of the main healing factors. Along with that it preserves all the flavonoids – the phytochemicals of the plant and of course the compounds or cannabinoids. Alcohol extraction is a very gentle way of extracting the cannabinoids and has been the go to for herbalists for centuries.

On the other hand CO2 extraction is harsher, it removes all of the very important chlorophyll and it not done properly will combust the terpenes and flavonoids leaving just the compounds. With a CO2 extraction you are not getting Whole Plant Therapy!

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CANNABIS AND THE ENDOCANNABINOID SYSTEM

HOW DOES CANNABIS WORK IN OUR BODIES? WHAT IS THE ENDOCANNABINOID SYSTEM?

It wasn’t until the 90’s that a vast receptor system was discovered in our bodies, they named this the endogenous endocannabinoid system.

Now where things get really interesting. The purpose of your endocannabinoid system is to create and maintain balance or homeostasis in your body, meaning when something in your body is overactive (stress, anxiety) or underactive (illness or pain) your Endocannabinoid system is supposed to kick into gear to bring you back into a state of balance.

Now it’s important to note that your own body actually produces these cannabinoids naturally and they are called Endocannabinoids. So the theory goes, when you’re totally healthy your own body is producing these endo- cannabinoids, it’s triggering your system to maintain balance keeping you happy and healthy and all is good.

Unfortunately with chronic stress, poor diet, and chronic pain our endocannabinoid system is negatively impacted which causes endocannabinoid dysfunction. Some of the diseases associated with this are: autoimmune diseases, epilepsy, migraine headaches, fibromyalgia, anxiety and depression just to name a few. Basically if your endocannabinoid system is not functioning well, you are out of balance.

So, the question is, how do we fix it?

ENDOCANNABINOID VS PHYTOCANNABINOID

And here is where it gets really fascinating. The compounds found in cannabis act as a lock and key within our body’s endocannabinoid system. If we have a cell that is depleted or out of balance and we ingest some CBD or CBG, the plant compound goes into our body, attaches to the receptor on our cell that needs some TLC and “wala” that cell is now more balanced. This is why we are seeing cannabis helping with absolutely everything, it works in harmony with our bodies and helps regulate balance in our cells.

Now this receptor system is literally everywhere in your body – it’s in your brain and your immune system, its in most of your major organs, in your lymph system, your digestive system, its in your spine, pretty much everywhere – well except for your brainstem which controls your breathing, and this is why it’s impossible to lethally overdose on cannabis like you can on opiates.

In essence when your body is not producing enough of these molecules to feed your system this plant is there to supplement and that’s why cannabis has been so useful in treating so many different conditions.

So if we put this all together it makes sense, you have this vast receptor system that exists everywhere in the body. This system is designed to trigger homeostasis to keep you in balance. If your body goes out of whack you need your endocannabinoid system to kick into gear and help you restore. If your body is not producing enough natural cannabinoids you need to supplement with an external source, which in this case is phyto (plant) cannabinoids from cannabis. And hopefully when taking the right dose you return to a happy and healthy self.

For so many years we’ve been told that cannabis is bad for us, for our brains, for our bodies and even bad for our society. But science is actually telling a very different story.

And what if cannabis is not only NOT bad for you but is actually the key to health, happiness and longevity. Because in so many areas of our society we’re already accustomed to taking herbs and plants to support our health and happiness, echinechea for colds, st Johns wort for depression, chamomile for calming and on and on. So maybe it’s time to take a closer look at this special plant and to be open to whether cannabis might have a profoundly positive impact on our health, well-being and society, don’t you think?

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CAN PETS BENEFIT FROM CBD OIL

CBD OIL FOR PETS

We’ve already covered the extensive benefits CBD oil has in treating symptoms in humans. It turns out that CBD oil may be just as beneficial for our beloved pets, too. The compound known as cannabidiol, or CBD, has opened up avenues of alternative therapy for pets suffering from any number of issues. CBD is non-psychoactive, unlike its sister compound, tetrahydrocannabinol, or THC. However, due to the entourage effect, CBD works best when it is paired with small amounts of THC even in animals.

WHAT CAN CBD OIL TREAT IN OUR PETS?

Like in humans, CBD oil for pets can treat a number of things, both in cats and in dogs. The following list is far from complete, but these are some common ailments in pets that CBD oil can help treat.

DOGS:

  • Lack of appetite
  • Anxiety due to separation, thunderstorms, fireworks, and other loud noises
  • Nausea
  • Calms for trips to the vet
  • Muscles spasms and seizures
  • Pain from cancer or arthritis
  • Grumpiness or aggression towards other animals

CATS:

  • Poor appetite
  • Constant hiding
  • Fear of the litter box
  • Eating inappropriate objects
  • Calms for vet trips
  • Aggression towards other animals
  • Distress from an environmental change

That sounds great for your furbaby, doesn’t it?

HOW CAN CBD TREATMENTS BE ADMINISTERED?

It might be hard to train Fido or Fluffy to take a hit from a vaporizer, but there are definitely ways to get CBD treatments into your pet. Like in humans, pets can ingest CBD edibles, tinctures, and even use topical treatments.

EDIBLES

Pet edibles are generally made by infusing CBD oil into cat or dog treats that taste great. Everyone with a pet knows how hard it can be to get them to take medication. They can eat around that piece of cheese and leave the pill behind. Since CBD edible treats come in flavors both cats and dogs enjoy, there’s little hassle. Keep in mind that giving a pet an edible is exactly like consuming one yourself. It will take time to work its way through the digestive system and kick in.

TINCTURES

Tinctures are prepared by infusing CBD compounds with mixtures of vegetable glycerin, oil, or alcohol. They are then placed using a dropper beneath the animal’s tongue. Tinctures are a great starting point and also great for relieving mild symptoms. Tinctures also allow for better dosage control and immediate relief.

TOPICALS

Like tinctures and edibles, topicals are CBD-infused oils and creams which are then applied locally to relieve pain and inflammation from conditions like arthritis. They can also be used to treat skin sensitivities due to allergies. Some of the topicals for itchiness imbue a menthol to help cool irritated skin, further calming the dog or cat’s symptoms. CBD topicals may be the best treatment for skin conditions and arthritis because it can offer immediate, localized relief.

Shampoos

CBD infused shampoo is a great way to help your pet with dry-itchy skin or life-less fur. When you massage the shampoo into the fur, make sure you leave it on for a few minutes as you rub it into the skin. FlowerChild CBD has a wonderful anti-itch CBD shampoo for Pets that is all natural. Not only does the CBD work it’s way into the skin to relieve pain and inflammation, but the natural ingredients in the shampoo help sooth irritated skin and leave your pet smelling great and feeling more comfortable.

DOSAGE

Dosage for your pet is an extremely important factor to consider and is based upon the pet’s weight. A general guideline is 1mg – 5mg per 10lbs of body weight. Most cats would do with a dosage of 1mg. For dogs, as they get larger and weigh more, the higher the dosage is required. Another good rule of thumb is to start with a dose on the lower end and monitor your pet for any side effects. Changes usually occur within an hour. If you see no changes, you might want to increase the dosage.

For pain relief, treatment should be given about once every eight hours. If you are trying to correct unwanted behaviors, twice per day is optimal. Keep in mind that it might take more than one treatment to begin to see improvement.

There is little to no overdose risk with pure CBD. However, if your CBD treatment contains small amounts of THC, monitor your pet for signs of THC toxicity – basically, they may act “high.” An animal suffering from THC toxicity may have problems standing, walking, or trouble eating.

We all love our pets. And when they suffer from debilitating ailments, we want to help treat those symptoms as best we can. Always talk to your vet before beginning any treatment regimen. Many vets have become familiar with the benefits CBD oil has for our animals and should be able to recommend the appropriate treatment for your pet.

IF YOU ARE INTERESTED IN USING CANNABIS FOR PETS, WE RECOMMEND…

At KanaRelief we recommend our CBD Tincture for Pets. This tinctures has been specially formulated for animals with a very high CBD to THC ratio. It is a medicinal cannabis CBD not a industrial hemp CBD! see What is the Difference between industrial and medicinal hemp CBD? THC is what gets you high. CBD does not. THC is necessary in the blend to work synergistically with the CBD, but huge amounts of THC are not necessary to receive the medical benefits of the cannabis.

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FOUR CRITERIA FOR ASSURING CANNABIS IS MEDICAL QUALITY

By Janna Champagne, BSN, RN – http://www.integratedholisticcare.comhttps://www.facebook.com/integratedholisticcare

As a holistic nurse who specializes in application of medical cannabis therapy, knowing which formulations are optimal for targeting patient’s health goals comes with the territory. After years of working with clients using a variety of cannabis products, I began noticing a trend: that different extraction and production methods exert very different results. This prompted intensive research into different types of cannabis formulations, which led to creation of the following optimal criteria for medical cannabis products. Please know I do not benefit from the sales of any products, so my perspective is completely objective and without profit-bias or personal gain.

In order to understand these criteria, it’s helpful to know a bit about the Endocannabinoid System (ECS). Many clients (including fellow medical professionals) have never heard about this master control system in our bodies, much thanks to our recent cannabis prohibition in the US. Now that cannabis is becoming more readily accessible, we are researching and learning that it contains vital nutrients needed to support optimal health balance. Cannabinoids found in the cannabis plant, such as THC and CBD, attach with ECS receptors in our bodies, which promotes internal homeostasis or balance. We know that the underlying cause of disease is imbalance, so this balancing “Entourage Effect” or synergy of cannabis can be profoundly therapeutic for improving the root cause of symptoms (4).

Following are the criteria we deem important for safe and effective medical cannabis use. We educate these criteria to every client we serve, since our goal is ensuring that cannabis patients find the highest-quality medical products available.

  1. Certified Clean/Organic: This may seem like an obvious requirement, for those who understand the harm that toxins may cause. Unfortunately, USDA Organic certification is not yet available for cannabis farming/processing, so we rely on labs to rule out any toxic pesticide, fertilizer, mold, or heavy metal contamination. We know, especially when working with already sick patients, that adding toxic exposure may be harmful to their health, and could potentially negate any benefit received from cannabis otherwise. The recent theory linking Cannabis Hyperemesis Syndrome, or excessive nausea, vomiting and abdominal upset, with Neem pesticide toxicity (same symptoms) further supports the importance of using lab testing to ensure product is clear of toxins, and verified safe for medical use (10).
  2. Lab tested: California is one of a few states that are fortunate in this regard, as they require every product on a dispensary shelf to be lab tested by a state-certified facility. Lab testing is important to know cannabinoid content, potency or strength, and (as already mentioned) to rule out contamination with toxins. Lab testing allows clients to consistently dose with improved accuracy, which is important when using cannabis for health purposes. Labs are the only conclusive method for knowing exactly what’s in a formulation, without reliance on strain name (which may not be accurate) to know which components are present.
    Terpene lab results reflecting the cannabis strain’s essential oil profile are not as commonly available. When available, having this information is optimal to predict a cannabis product’s therapeutic benefits, and the terpene profile is also used to determine whether a product is categorized as sativa (energizing) or indica (sedating) (11).
  3. Whole Plant: Products that concentrate the cannabis plant as nature intended are the best options when the goal is improved health status. Cannabis formulations extracted using food grade ethanol or infusion methods are preferred to meet these criteria. Whole plant is defined as having all of the original flower-derived cannabis ingredients remain fully intact in the final product.
    Cannabis is a very complex plant, containing over 140 cannabinoids, 200 terpenes (essential oils), bioflavonoids, chlorophyll, essential fatty acids, and antioxidants (1). Many of the new and popular cannabis extraction methods in today’s cannabis industry, such as CO2 extraction, isolation, or fractionation, remove many of these ingredients contributing to the Entourage Effect (8). This is important since we know that whole plant formulations, containing all components of the plant, are best for balancing the body. It’s the balancing effect (homeostasis) that we specifically seek when the goal is improved medical outcomes that reach beyond simply managing symptoms (4). Research comparing the efficacy of whole plant cannabis formulations with isolates clearly reflects that isolates, with or without added terpenes, aren’t as effective for exerting the balance we seek for optimal medical outcomes (2, 3, 6).
  4. No industrial hemp-derived products: The most potent spectrum of cannabinoids and synergistic components is found in formulations derived from cannabis flower. Since industrial hemp is sparse in flowers, often producers source oil from less optimal parts of the industrial hemp plant, such as the stalks and stems. While industrial hemp has many applicable uses, including textiles, bioaccumulation (cleans soil), building materials like Hempcrete, when it comes to medicinal potency, industrial hemp leaves a lot to be desired (9).
    To clarify, many CBD producers have a USDA hemp license allowing them to legally produce and distribute hemp throughout the United States, because their cannabis flower products meet the federal hemp regulations (by containing less than 0.3% THC). There is a new term called “Medical Hemp” being coined by optimal CBD oil producers, to differentiate their products derived from high CBD cannabis flower qualifying as hemp, the best choice for medical use. Medical hemp products have the added convenience of shipping legally anywhere in the United States. However, clients still need to be aware of their local laws on hemp CBD, since some states don’t recognize federal CBD hemp regulations.

There is a lot of confusion around choosing the best cannabis products, and the intent of this article is to guide medically-focused cannabis patients and ensure they understand which qualities to seek when purchasing cannabis products. We encourage anyone who is new to cannabis, suffering from a complex medical condition, or taking pharmaceutical medications to seek individualized consultation and education from a qualified medical professional for a targeted care plan. Using an individualized approach with medical guidance further reduces possible risk factors, allowing clients to gain the most benefit from their medical cannabis therapy. To find out more about our services, please visit: http://www.integratedholisticcare.com

References:
1. Echo (2017). Other compounds in cannabis. Retrieved from: https://echoconnection.org/other-compounds-in-cannabis-terpenes-chlorophyll-etc/
2. Blasco-Benito (2017). Appraising the entourage effect. Retrieved from: https://www.ncbi.nlm.nih.gov/labs/pubmed/29940172-appraising-the-entourage-effect-antitumor-action-of-a-pure-cannabinoid-versus-a-botanical-drug-preparation-in-preclinical-models-of-breast-cancer/
3. Pamplona (2018). Potential clinical benefits of CBD-rich Cannabis extracts over purified CBD in treatment-resistant epilepsy: observational data meta-analysis. Retrieved from: https://www.biorxiv.org/content/biorxiv/early/2017/11/01/212662.full.pdf
4. Russo, E. (2001). Cannabis and cannabis extracts: greater than the sum of their parts? British Journal of Pharmacology. Retrieved from: http://cannabis-med.org/data/pdf/2001-03-04-7.pdf
5. Echo (2017). Major and minor cannabinoids in cannabis. Retrieved from: https://echoconnection.org/a-look-at-the-major-and-minor-cannabinoids-found-in-cannabis/
6. Gallily (2015). Overcoming the Bell-Shaped Dose-Response of Cannabidiol by Using Cannabis Extract Enriched in Cannabidiol. Retrieved from: http://www.scirp.org/Journal/PaperInformation.aspx?PaperID=53912#.VP4EIildXvY
7. Fundacion Canna (2017) Cannabis bioflavonoids. Retrieved from: http://www.fundacion-canna.es/en/flavonoids
8. Echo (2017). CBD Alcohol or CO2 Extraction. Retrieved at: http://www.cbd-hemp-oil-drops.com/articles/57-cbd-alcohol-or-co2-extraction
9. Price, M (2015). The difference between hemp and cannabis. Medical Jane. Retrieved online at: https://www.medicaljane.com/2015/01/14/the-differences-between-hemp-and-cannabis/
10. Mishra, A., & Dave, N. (2013). Neem oil poisoning: Case report of an adult with toxic encephalopathy. Indian Journal of Critical Care Medicine : Peer-Reviewed, Official Publication of Indian Society of Critical Care Medicine, 17(5), 321–322. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3841499/
11. Cannabis Safety Institute (2014). Standards for cannabis testing laboratories. Retrieved online at: http://cannabissafetyinstitute.org/wp-content/uploads/2015/01/Standards-for-Cannabis-Testing-Laboratories.pdf